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Article

The Role of Pharmacogenetics in Smoking.

Clinical pharmacology and therapeutics - 1 Sept 2021

El-Boraie Ahmed, Tyndale Rachel F

Abstract excerpt

Smoking continues to be the leading preventable contributor to death worldwide. Twin studies have suggested a significant genetic contribution underlying most smoking behaviors (40-70% heritability estimates). Candidate gene studies of smoking phenotypes have identified several pharmacogenes implicated in nicotine's pharmacokinetics (CYP2A6, CYP2B6, CYP2A13, FMOs, UGTs, and OCT2), and nicotine's pharmacodynamic...

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Source

Identifiers

PMID: 34165800
DOI: 10.1002/cpt.2345

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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