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Article

Novel Association of Genetic Markers Affecting CYP2A6 Activity and Lung Cancer Risk.

Cancer research - 1 Oct 2016

Patel Yesha M, Park Sunghim L, Han Younghun, Wilkens Lynne R, Bickeböller Heike, Rosenberger Albert, Caporaso Neil, Landi Maria Teresa, Brüske Irene, Risch Angela, Wei Yongyue, Christiani David C, Brennan Paul, Houlston Richard, McKay James, McLaughlin John, Hung Rayjean, Murphy Sharon, Stram Daniel O, Amos Christopher, Le Marchand Loïc

Abstract excerpt

Metabolism of nicotine by cytochrome P450 2A6 (CYP2A6) is a suspected determinant of smoking dose and, consequently, lung cancer risk. We conducted a genome-wide association study (GWAS) of CYP2A6 activity, as measured by the urinary ratio of trans-3'-hydroxycotinine and its glucuronide conjugate over cotinine (total 3HCOT/COT), among 2,239 smokers in the Multiethnic Cohort (MEC) study. We identified 248 CYP2A6...

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Identifiers

PMID: 27488534
DOI: 10.1158/0008-5472.CAN-16-0446
PMCID: PMC5050097

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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