Fine-mapping the CYP2A6 regional association with nicotine metabolism among African American smokers.

doi:10.1038/s41380-024-02703-5

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Article

Fine-mapping the CYP2A6 regional association with nicotine metabolism among African American smokers.

Molecular psychiatry - 1 Mar 2025

Pouget Jennie G, Giratallah Haidy, Langlois Alec W R, El-Boraie Ahmed, Lerman Caryn, Knight Jo, Cox Lisa Sanderson, Nollen Nikki L, Ahluwalia Jasjit S, Benner Christian, Chenoweth Meghan J, Tyndale Rachel F

Abstract excerpt

The nicotine metabolite ratio (NMR; 3'hydroxycotinine/cotinine) is a stable biomarker for CYP2A6 enzyme activity and nicotine clearance, with demonstrated clinical utility in personalizing smoking cessation treatment. Common genetic variation in the CYP2A6 region is strongly associated with NMR in smokers. Here, we investigated this regional association in more detail. We evaluated the association of CYP2A6...

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Topics

Adult
Female
Humans
Male
Middle Aged
Alleles

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Bayes Theorem

Black or African American

Cotinine

Cytochrome P-450 CYP2A6

Genome-Wide Association Study

Genotype

Nicotine

Polymorphism, Single Nucleotide

Smokers

Smoking

Smoking Cessation

White

Source

Open in PubMed

Identifiers

PMID: 39217253
DOI: 10.1038/s41380-024-02703-5

Genes

CYP2A6

Provenance

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