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Article

The contribution of common CYP2A6 alleles to variation in nicotine metabolism among European-Americans.

Pharmacogenetics and genomics - 1 Jul 2011

Bloom Joseph, Hinrichs Anthony L, Wang Jen C, von Weymarn Linda B, Kharasch Evan D, Bierut Laura J, Goate Alison, Murphy Sharon E

Abstract excerpt

OBJECTIVE: To study the association between cytochrome P450 2A6 (CYP2A6) genotype and metabolism of nicotine to cotinine, identify functional polymorphisms, and develop a predictive genetic model of nicotine metabolism. METHODS: The conversion of deuterated (D2)-nicotine to D2-cotinine was quantified in 189 European-Americans and the contribution of CYP2A6 genotype to variability in first-pass nicotine metabolism...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21597399
DOI: 10.1097/FPC.0b013e328346e8c0
PMCID: PMC3116045

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