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Article

Transferability of Ancestry-Specific and Cross-Ancestry CYP2A6 Activity Genetic Risk Scores in African and European Populations.

Clinical pharmacology and therapeutics - 1 Oct 2021

El-Boraie Ahmed, Chenoweth Meghan J, Pouget Jennie G, Benowitz Neal L, Fukunaga Koya, Mushiroda Taisei, Kubo Michiaki, Nollen Nicole L, Sanderson Cox Lisa, Lerman Caryn, Knight Jo, Tyndale Rachel F

Abstract excerpt

The Nicotine Metabolite Ratio (NMR; 3-hydroxycotinine/cotinine), a highly heritable index of nicotine metabolic inactivation by the CYP2A6 enzyme, is associated with numerous smoking behaviors and diseases, as well as unique cessation outcomes. However, the NMR cannot be measured in nonsmokers, former smokers, or intermittent smokers, for example, in evaluating tobacco-related disease risk. Traditional...

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Source

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Identifiers

PMID: 33300144
DOI: 10.1002/cpt.2135
PMCID: PMC8187466

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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