Article
The contribution of common genetic variation to nicotine and cotinine glucuronidation in multiple ethnic/racial populations.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jan 2015
Patel Yesha M, Stram Daniel O, Wilkens Lynne R, Park Sung-Shim L, Henderson Brian E, Le Marchand Loic, Haiman Christopher A, Murphy Sharon E
Abstract excerpt
BACKGROUND: The lung cancer risk of smokers varies by race/ethnicity even after adjustment for smoking. Evaluating the role of genetics in nicotine metabolism is likely important in understanding these differences, as disparities in risk may be related to differences in nicotine dose and metabolism. METHODS: We conducted a genome-wide association study in search of common genetic variants that predict nicotine...
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