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Article

Analyses of nicotine metabolism biomarker genetics stratified by sex in African and European Americans.

Scientific reports - 1 Oct 2021

Chenoweth Meghan J, Cox Lisa Sanderson, Nollen Nikki L, Ahluwalia Jasjit S, Benowitz Neal L, Lerman Caryn, Knight Jo, Tyndale Rachel F

Abstract excerpt

Nicotine is inactivated by the polymorphic CYP2A6 enzyme to cotinine and then to 3'hydroxycotinine. The Nicotine Metabolite Ratio (NMR; 3'hydroxycotinine/cotinine) is a heritable nicotine metabolism biomarker, varies with sex and ancestry, and influences smoking cessation and disease risk. We conducted sex-stratified genome-wide association studies of the NMR in European American (EA) and African American (AA)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34599228
DOI: 10.1038/s41598-021-98883-z
PMCID: PMC8486765

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