Genetics of osteoarthritis.

doi:10.1016/j.joca.2021.03.002

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Article

Genetics of osteoarthritis.

Osteoarthritis and cartilage - 1 May 2022

Aubourg G, Rice S J, Bruce-Wootton P, Loughlin J

Abstract excerpt

Osteoarthritis genetics has been transformed in the past decade through the application of large-scale genome-wide association scans. So far, over 100 polymorphic DNA variants have been associated with this common and complex disease. These genetic risk variants account for over 20% of osteoarthritis heritability and the vast majority map to non-protein coding regions of the genome where they are presumed to act...

Topics

DNA Methylation
Epigenomics
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Osteoarthritis
Polymorphism, Single Nucleotide

Source

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Identifiers

PMID: 33722698
DOI: 10.1016/j.joca.2021.03.002
PMCID: PMC9067452

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