Article
Transcriptome analysis in osteoarthritis primary tissues identifies high-confidence effector genes.
Nature communications - 29 Jun 2026
Katsoula Georgia, Arruda Ana Luiza, Tutino Mauro, Reimann Ene, Bittner Norbert, Kreitmaier Peter, Shah Karan M, Swift Diane, Southam Lorraine, Suutre Siim, Silva Galadriel Lucía Velázquez, Tootsi Kaspar, Märtson Aare, Mägi Reedik, Mark Wilkinson J, Zeggini Eleftheria
Abstract excerpt
Osteoarthritis, a whole-joint degenerative disorder, is a major public health burden that affects nearly 600 million individuals worldwide, with no disease-modifying treatment. Molecular profiling of relevant tissues is crucial for understanding the biology of disease development. Here, we generate a comprehensive map of cis- and trans- transcriptional regulation in disease-relevant primary tissues from knee...
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