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Article

A common SNP in Chrna5 enhances morphine reward in female mice.

Neuropharmacology - 1 Nov 2022

Brynildsen Julia K, Yang Kechun, Lemchi Crystal, Dani John A, De Biasi Mariella, Blendy Julie A

Abstract excerpt

The single nucleotide polymorphism (SNP) D398N (rs16969968) in CHRNA5, the gene encoding the α5 subunit of the nicotinic acetylcholine receptors (nAChR), has been associated with both nicotine and opiate dependence in human populations. Expression of this SNP on presynaptic VTA dopaminergic (DA) neurons is known to cause a reduction in calcium signaling, leading to alterations in transmitter signaling and altered...

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Identifiers

PMID: 35973602
DOI: 10.1016/j.neuropharm.2022.109218

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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