Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Linking the CHRNA5 SNP to drug abuse liability: From circuitry to cellular mechanisms.

Neuropharmacology - 15 Mar 2021

Brynildsen Julia K, Blendy Julie A

Abstract excerpt

Genetics are known to be a significant risk factor for drug abuse. In human populations, the single nucleotide polymorphism (SNP) D398N in the gene CHRNA5 has been associated with addiction to nicotine, opioids, cocaine, and alcohol. In this paper, we review findings from studies in humans, rodent models, and cell lines and provide evidence that collectively suggests that the Chrna5 SNP broadly influences the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain
Share to Genetic Linkage
Share to Nerve Net

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Nerve Tissue Proteins

Share to Neuroimaging

Share to Polymorphism, Single Nucleotide

Share to Receptors, Nicotinic

Share to Substance-Related Disorders

Source

Open in PubMed Open full text

Identifiers

PMID: 33539855
DOI: 10.1016/j.neuropharm.2021.108480
PMCID: PMC7958463

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Linking the CHRNA5 SNP to drug abuse liability: From circuitry to cellular mechanisms.PMID 33539855Read ↗

Association of CHRNA5 Gene Variants with Crack Cocaine Addiction.Semantic proximity Read ↗

Common single nucleotide variants underlying drug addiction: more than a decade of research.Semantic proximity Read ↗

Role of <i>chrna5</i> in multi-substance preference and phenotypes comorbid with the development of substance dependenceSemantic proximity Read ↗

Variation in the gene coding for the M5 muscarinic receptor (CHRM5) influences cigarette dose but is not associated with dependence to drugs of addiction: evidence from a prospective population based cohort study of young adults.Semantic proximity Read ↗

Genetic susceptibility to nicotine addiction: Advances and shortcomings in our understanding of the CHRNA5/A3/B4 gene cluster contribution.Semantic proximity Read ↗

Variants in nicotinic receptors and risk for nicotine dependence.Semantic proximity Read ↗

Variation in nicotinic acetylcholine receptor genes is associated with multiple substance dependence phenotypes.Semantic proximity Read ↗

The CHRNA5-A3-B4 gene cluster in nicotine addiction.Semantic proximity Read ↗

Profound alteration in reward processing due to a human polymorphism in CHRNA5: a role in alcohol dependence and feeding behaviorSemantic proximity Read ↗

From men to mice: CHRNA5/CHRNA3, smoking behavior and disease.Semantic proximity Read ↗

Genetic risk for nicotine dependence in the cholinergic system and activation of the brain reward system in healthy adolescents.Semantic proximity Read ↗

Increased nicotine response in iPSC-derived human neurons carrying the CHRNA5 N398 allele.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.