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Article

Genetic variation within the Chrna7 gene modulates nicotine reward-like phenotypes in mice.

Genes, brain, and behavior - 1 Feb 2014

Harenza J L, Muldoon P P, De Biasi M, Damaj M I, Miles M F

Abstract excerpt

Mortality from tobacco smoking remains the leading cause of preventable death in the world, yet current cessation therapies are only modestly successful, suggesting new molecular targets are needed. Genetic analysis of gene expression and behavior identified Chrna7 as potentially modulating nicotine place conditioning in the BXD panel of inbred mice. We used gene targeting and pharmacological tools to confirm the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24289814
DOI: 10.1111/gbb.12113
PMCID: PMC3919514

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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