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Article

Distinct Chrna5 mutations link excessive alcohol use to types I/II vulnerability profiles and IPN GABAergic neurons.

Translational psychiatry - 6 Nov 2024

Tochon Léa, Henkous Nadia, Besson Morgane, Maskos Uwe, David Vincent

Abstract excerpt

Genome wide association and animal studies have implicated genetic variations in CHRNΑ5, encoding the α5 subunit-containing nicotinic acetylcholine receptors (α5*nAChRs), as a risk factor for developing alcohol use disorders (AUDs). To understand how α5*nAChR mutations may influence alcohol (EtOH) drinking behavior, we used a two-bottle choice procedure with intermittent access to alcohol in male and female...

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Alcohol Drinking
Alcoholism
Anxiety
Behavior, Animal
Ethanol

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

GABAergic Neurons

Impulsive Behavior

Receptors, Nicotinic

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Identifiers

PMID: 39505853
DOI: 10.1038/s41398-024-03164-8
PMCID: PMC11541707

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