Increased nicotine response in iPSC-derived human neurons carrying the CHRNA5 N398 allele.

doi:10.1038/srep34341

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Article

Increased nicotine response in iPSC-derived human neurons carrying the CHRNA5 N398 allele.

Scientific reports - 4 Oct 2016

Oni Eileen N, Halikere Apoorva, Li Guohui, Toro-Ramos Alana J, Swerdel Mavis R, Verpeut Jessica L, Moore Jennifer C, Bello Nicholas T, Bierut Laura J, Goate Alison, Tischfield Jay A, Pang Zhiping P, Hart Ronald P

Abstract excerpt

Genetic variation in nicotinic receptor alpha 5 (CHRNA5) has been associated with increased risk of addiction-associated phenotypes in humans yet little is known the underlying neural basis. Induced pluripotent stem cells (iPSCs) were derived from donors homozygous for either the major (D398) or the minor (N398) allele of the nonsynonymous single nucleotide polymorphism (SNP), rs16969968, in CHRNA5. To understand...

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Identifiers

PMID: 27698409
DOI: 10.1038/srep34341
PMCID: PMC5048107

Genes

CHRNA5

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