Article

Role of <i>chrna5</i> in multi-substance preference and phenotypes comorbid with the development of substance dependence

2025-07-15

Abstract excerpt

Addiction to nicotine and alcohol continues to be a leading cause of death and loss of productivity as measured in disability-adjusted life years. Polymorphisms in the nicotinic acetylcholine receptor subunit α5 (CHRNA5) have been identified as risk factors associated with nicotine dependence in human genetic studies and rodent models. Whether the chrna5 function is independently relevant to phenotypes associated...

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Literature Corpus work: 6dbd6455-4c11-5842-8f6d-f828e50b1bf7
DOI: 10.1101/2025.07.10.663858

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