Article
Alterations in alpha5* nicotinic acetylcholine receptors result in midbrain- and hippocampus-dependent behavioural and neural impairments.
Psychopharmacology - 1 Sept 2016
Besson Morgane, Guiducci Stefania, Granon Sylvie, Guilloux Jean-Philippe, Guiard Bruno, Repérant Christelle, Faure Philippe, Pons Stéphanie, Cannazza Giuseppe, Zoli Michele, Gardier Alain M, Maskos Uwe
Abstract excerpt
RATIONALE: Evidence links alterations in α5-containing nicotinic receptors (α5*-nAChRs) to nicotine addiction. Notably, the rs16969968 polymorphism in the α5 gene (α5SNP) increases the risk for heavy smoking and impairs nicotine-rewarding properties in mice. Additional work is needed to understand how native and polymorphic α5*-nAChRs contribute to processes associated with the risk for nicotine addiction....
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