The interaction of the Chrna5 D398N variant with developmental nicotine exposure.

doi:10.1111/gbb.12474

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Article

The interaction of the Chrna5 D398N variant with developmental nicotine exposure.

Genes, brain, and behavior - 1 Sept 2018

O'Neill H C, Wageman C R, Sherman S E, Grady S R, Marks M J, Stitzel J A

Abstract excerpt

A single nucleotide polymorphism (SNP) in CHRNA5 (rs16969968, change from an aspartic acid [D] to asparagine [N] at position 398 of the human α5 nicotinic acetylcholine receptor subunit) has been associated with increased risk for nicotine dependence. Consequently, carriers of the risk variant may be at elevated risk for in utero nicotine exposure. To assess whether this gene-environment interaction might impact...

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Identifiers

PMID: 29573323
DOI: 10.1111/gbb.12474
PMCID: PMC7313682

Genes

CHRNA5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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