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Article

Overexpression of the CHRNA5/A3/B4 genomic cluster in mice increases the sensitivity to nicotine and modifies its reinforcing effects.

Amino acids - 1 Aug 2012

Gallego Xavier, Molas Susanna, Amador-Arjona Alejandro, Marks Michael J, Robles Noemí, Murtra Patricia, Armengol Lluís, Fernández-Montes Rubén D, Gratacòs Mònica, Pumarola Martí, Cabrera Roberto, Maldonado Rafael, Sabrià Josefa, Estivill Xavier, Dierssen Mara

Abstract excerpt

Nicotinic acetylcholine receptors (nAChRs) are ligand-gated pentameric ion channels that account for the effects of nicotine. Recent genetic studies have highlighted the importance of variants of the CHRNA5/A3/B4 genomic cluster in human nicotine dependence. Among these genetic variants those found in non-coding segments of the cluster may contribute to the pathophysiology of tobacco use through alterations in...

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Corpus Striatum
Genetic Engineering
Nicotine
Proto-Oncogene Proteins c-fos

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Radionuclide Imaging

Receptors, Nicotinic

Self Administration

Tobacco Use Disorder

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Identifiers

PMID: 22101982
DOI: 10.1007/s00726-011-1149-y

Genes

CHRNA5

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