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Article

Mutation of the α5 nicotinic acetylcholine receptor subunit increases ethanol and nicotine consumption in adolescence and impacts adult drug consumption.

Neuropharmacology - 15 Sept 2022

Quijano Cardé Natalia A, Shaw Jessica, Carter Christina, Kim Seung, Stitzel Jerry A, Venkatesh Shyamala K, Ramchandani Vijay A, De Biasi Mariella

Abstract excerpt

Alcohol and nicotine are commonly used during adolescence, establishing long-lasting neuroplastic alterations that influence subsequent drug use and abuse. Drinking- and smoking-related traits have been extensively associated with variation in CHRNA5 - the gene that encodes the α5 subunit of neuronal nicotinic acetylcholine receptors (nAChRs). The single nucleotide polymorphism (SNP) rs16969968 in CHRNA5 encodes...

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Identifiers

PMID: 35752273
DOI: 10.1016/j.neuropharm.2022.109170
PMCID: PMC9308728

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