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Article

The Rab GTPase activating protein TBC-2 regulates endosomal localization of DAF-16 FOXO and lifespan.

PLoS genetics - 1 Aug 2022

Meraş İçten, Chotard Laëtitia, Liontis Thomas, Ratemi Zakaria, Wiles Benjamin, Seo Jung Hwa, Van Raamsdonk Jeremy M, Rocheleau Christian E

Abstract excerpt

FOXO transcription factors have been shown to regulate longevity in model organisms and are associated with longevity in humans. To gain insight into how FOXO functions to increase lifespan, we examined the subcellular localization of DAF-16 in C. elegans. We show that DAF-16 is localized to endosomes and that this endosomal localization is increased by the insulin-IGF signaling (IIS) pathway. Endosomal...

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Identifiers

PMID: 35913999
DOI: 10.1371/journal.pgen.1010328
PMCID: PMC9371356

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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