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Article

EAK-7 controls development and life span by regulating nuclear DAF-16/FoxO activity.

Cell metabolism - 7 Jul 2010

Alam Hena, Williams Travis W, Dumas Kathleen J, Guo Chunfang, Yoshina Sawako, Mitani Shohei, Hu Patrick J

Abstract excerpt

FoxO transcription factors control development and longevity in diverse species. Although FoxO regulation via changes in its subcellular localization is well established, little is known about how FoxO activity is regulated in the nucleus. Here, we show that the conserved C. elegans protein EAK-7 acts in parallel to the serine/threonine kinase AKT-1 to inhibit the FoxO transcription factor DAF-16. Loss of EAK-7...

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Identifiers

PMID: 20620993
DOI: 10.1016/j.cmet.2010.05.004
PMCID: PMC2907918

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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