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Article

DAF-16/FoxO in Caenorhabditis elegans and Its Role in Metabolic Remodeling.

Cells - 2 Jan 2020

Zečić Aleksandra, Braeckman Bart P

Abstract excerpt

DAF-16, the only forkhead box transcription factors class O (FoxO) homolog in Caenorhabditis elegans, integrates signals from upstream pathways to elicit transcriptional changes in many genes involved in aging, development, stress, metabolism, and immunity. The major regulator of DAF-16 activity is the insulin/insulin-like growth factor 1 (IGF-1) signaling (IIS) pathway, reduction of which leads to lifespan...

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Identifiers

PMID: 31906434
DOI: 10.3390/cells9010109
PMCID: PMC7017163

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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DAF-16/FoxO in Caenorhabditis elegans and Its Role in Metabolic Remodeling.PMID 31906434Read ↗

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