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The Rab GTPase activating protein TBC-2 regulates endosomal localization of DAF-16 FOXO and lifespan

2021-06-04

Abstract excerpt

<h4>ABSTRACT</h4> FOXO transcription factors have been shown to regulate longevity in model organisms and are associated with longevity in humans. To gain insight into how FOXO functions to increase lifespan, we examined the subcellular localization of DAF-16 in C. elegans. We show that DAF-16 is localized to endosomes and that this endosomal localization is increased by the insulin-IGF signaling (IIS) pathway....

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Identifiers and source

Literature Corpus work
37752a8f-a0ca-5fb7-b4eb-85d8cee7b6de
DOI
10.1101/2021.06.04.447106
Open publication

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The Rab GTPase activating protein TBC-2 regulates endosomal localization of DAF-16 FOXO and lifespanDOI 10.1101/2021.06.04.447106
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