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Article

APOBEC mutagenesis and selection for NFE2L2 contribute to the origin of lung squamous-cell carcinoma.

Lung cancer (Amsterdam, Netherlands) - 1 Sept 2022

Cannataro Vincent L, Kudalkar Shalley, Dasari Krishna, Gaffney Stephen G, Lazowski Heather M, Jackson Laura K, Yildiz Isil, Das Rahul K, Gould Rothberg Bonnie E, Anderson Karen S, Townsend Jeffrey P

Abstract excerpt

Lung squamous-cell carcinoma originates as a consequence of oncogenic molecular variants arising from diverse mutagenic processes such as tobacco, defective homologous recombination, aging, and cytidine deamination by APOBEC proteins. Only some of the many variants generated by these processes actually contribute to tumorigenesis. Therefore, molecular investigation of mutagenic processes such as cytidine...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 35872531
DOI: 10.1016/j.lungcan.2022.07.004
PMCID: PMC10126952

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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