Article
APOBEC3A catalyzes mutation and drives carcinogenesis in vivo.
The Journal of experimental medicine - 7 Dec 2020
Law Emily K, Levin-Klein Rena, Jarvis Matthew C, Kim Hyoung, Argyris Prokopios P, Carpenter Michael A, Starrett Gabriel J, Temiz Nuri A, Larson Lindsay K, Durfee Cameron, Burns Michael B, Vogel Rachel I, Stavrou Spyridon, Aguilera Alexya N, Wagner Sandra, Largaespada David A, Starr Timothy K, Ross Susan R, Harris Reuben S
Abstract excerpt
The APOBEC3 family of antiviral DNA cytosine deaminases is implicated as the second largest source of mutation in cancer. This mutational process may be a causal driver or inconsequential passenger to the overall tumor phenotype. We show that human APOBEC3A expression in murine colon and liver tissues increases tumorigenesis. All other APOBEC3 family members, including APOBEC3B, fail to promote liver tumor...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.