Article
Genomic Characterization Revealed PM2.5-Associated Mutational Signatures in Lung Cancer Including Activation of APOBEC3B.
Environmental science & technology - 2 May 2023
Fan Rongrong, Xu Lin, Cui Bowen, Li Daochuan, Sun Xueying, Qi Yuan, Rao Jianan, Wang Kai, Wang Cheng, Zhao Kunming, Zhao Yanjie, Dai Juncheng, Chen Wen, Shen Hongbing, Liu Yu, Yu Dianke
Abstract excerpt
Fine particulate matter (PM2.5) exposure causes DNA mutations and abnormal gene expression leading to lung cancer, but the detailed mechanisms remain unknown. Here, analysis of genomic and transcriptomic changes upon a PM2.5 exposure-induced human bronchial epithelial cell-based malignant transformed cell model in vitro showed that PM2.5 exposure led to APOBEC mutational signatures and transcriptional activation...
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