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APOBEC affects tumor evolution and age at onset of lung cancer in smokers

21 May 2025

Abstract excerpt

Most solid tumors harbor somatic mutations attributed to off-target activities of APOBEC3A (A3A) and/or APOBEC3B (A3B). However, how APOBEC3A/B enzymes affect tumor evolution in the presence of exogenous mutagenic processes is largely unknown. Here, multi-omics profiling of 309 lung cancers from smokers identifies two subtypes defined by low (LAS) and high (HAS) APOBEC mutagenesis. LAS are enriched for A3B-like...

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PMID: 40394004
DOI: 10.1038/s41467-025-59923-8

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