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Article

Use of Polygenic Risk Scores for Coronary Heart Disease in Ancestrally Diverse Populations.

Current cardiology reports - 1 Sept 2022

Dikilitas Ozan, Schaid Daniel J, Tcheandjieu Catherine, Clarke Shoa L, Assimes Themistocles L, Kullo Iftikhar J

Abstract excerpt

PURPOSE OF REVIEW: A polygenic risk score (PRS) is a measure of genetic liability to a disease and is typically normally distributed in a population. Individuals in the upper tail of this distribution often have relative risk equivalent to that of monogenic form of the disease. The majority of currently available PRSs for coronary heart disease (CHD) have been generated from cohorts of European ancestry (EUR) and...

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Identifiers

PMID: 35796859
DOI: 10.1007/s11886-022-01734-0
PMCID: PMC9645134

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