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Article

Polygenic risk scores for cardiometabolic traits demonstrate importance of ancestry for predictive precision medicine.

Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing - 1 Jan 2025

Kember Rachel L, Verma Shefali S, Verma Anurag, Xiao Brenda, Lucas Anastasia, Kripke Colleen M, Judy Renae, Chen Jinbo, Damrauer Scott M, Rader Daniel J, Ritchie Marylyn D

Abstract excerpt

Polygenic risk scores (PRS) have predominantly been derived from genome-wide association studies (GWAS) conducted in European ancestry (EUR) individuals. In this study, we present an in-depth evaluation of PRS based on multi-ancestry GWAS for five cardiometabolic phenotypes in the Penn Medicine BioBank (PMBB) followed by a phenome-wide association study (PheWAS). We examine the PRS performance across all...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39670412
DOI: 10.1142/9789819807024_0056

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CAD
DBP

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