Structural variants shape driver combinations and outcomes in pediatric high-grade glioma.

doi:10.1038/s43018-022-00403-z

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Article

Structural variants shape driver combinations and outcomes in pediatric high-grade glioma.

Nature cancer - 1 Aug 2022

Dubois Frank P B, Shapira Ofer, Greenwald Noah F, Zack Travis, Wala Jeremiah, Tsai Jessica W, Crane Alexander, Baguette Audrey, Hadjadj Djihad, Harutyunyan Ashot S, Kumar Kiran H, Blattner-Johnson Mirjam, Vogelzang Jayne, Sousa Cecilia, Kang Kyung Shin, Sinai Claire, Wang Dayle K, Khadka Prasidda, Lewis Kathleen, Nguyen Lan, Malkin Hayley, Ho Patricia, O'Rourke Ryan, Zhang Shu, Gold Rose, Deng Davy, Serrano Jonathan, Snuderl Matija, Jones Chris, Wright Karen D, Chi Susan N, Grill Jacques, Kleinman Claudia L, Goumnerova Liliana C, Jabado Nada, Jones David T W, Kieran Mark W, Ligon Keith L, Beroukhim Rameen, Bandopadhayay Pratiti

Abstract excerpt

We analyzed the contributions of structural variants (SVs) to gliomagenesis across 179 pediatric high-grade gliomas (pHGGs). The most recurrent SVs targeted MYC isoforms and receptor tyrosine kinases (RTKs), including an SV amplifying a MYC enhancer in 12% of diffuse midline gliomas (DMG), indicating an underappreciated role for MYC in pHGG. SV signature analysis revealed that tumors with simple signatures were...

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PMID: 35788723
DOI: 10.1038/s43018-022-00403-z
PMCID: PMC10365847

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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