Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Modeling the Landscape of Histone-Mutant Pediatric High-Grade Gliomas: A Study in Partner Alterations.

Cancer discovery - 7 Jul 2023

Lubanszky Evan, Hawkins Cynthia

Abstract excerpt

SUMMARY: Pediatric high-grade gliomas represent a group of deadly, heterogeneous tumors, often driven by histone mutations and the accumulation of clonal mutations, correlating with different tumor types, locations, and age of onset. In this study, McNicholas and colleagues present 16 in vivo models of histone-driven gliomas to investigate subtype-specific tumor biology and treatment options. See related article...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain Neoplasms
Share to Child
Share to Glioma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histones

Share to Mutation

Source

Identifiers

PMID: 37416991
DOI: 10.1158/2159-8290.CD-23-0495

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Modeling the Landscape of Histone-Mutant Pediatric High-Grade Gliomas: A Study in Partner Alterations.PMID 37416991Read ↗

A Compendium of Syngeneic, Transplantable Pediatric High-Grade Glioma Models Reveals Subtype-Specific Therapeutic Vulnerabilities.Semantic proximity Read ↗

Histone-Mutant Glioma: Molecular Mechanisms, Preclinical Models, and Implications for Therapy.Semantic proximity Read ↗

Epigenetic programming of pediatric high-grade glioma: Pushing beyond proof of concept to clinical benefitSemantic proximity Read ↗

A living pediatric brain tumor atlas reveals histomolecular diversity and therapeutic vulnerabilities for precision neuro-oncologySemantic proximity Read ↗

Epigenetic reprogramming in pediatric gliomas: from molecular mechanisms to therapeutic implications.Semantic proximity Read ↗

Structural variants shape driver combinations and outcomes in pediatric high-grade glioma.Semantic proximity Read ↗

Mutations in chromatin machinery and pediatric high-grade glioma.Semantic proximity Read ↗

Structural variants shape driver combinations and outcomes in pediatric high-grade gliomaSemantic proximity Read ↗

Patient-derived models recapitulate heterogeneity of molecular signatures and drug response in pediatric high-grade glioma.Semantic proximity Read ↗

Somatic structural variations in pediatric brain tumors.Semantic proximity Read ↗

Comprehensive Genomic Profiling of 282 Pediatric Low- and High-Grade Gliomas Reveals Genomic Drivers, Tumor Mutational Burden, and Hypermutation Signatures.Semantic proximity Read ↗

Pediatric High Grade Glioma Resources From the Children’s Brain Tumor Tissue Consortium (CBTTC) and Pediatric Brain Tumor Atlas (PBTA)Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.