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Pediatric Hemispheric High-Grade Gliomas and H3.3-G34 Mutation: A Review of the Literature on Biological Features and New Therapeutic Strategies.

Genes - 6 Aug 2024

Bonada Marta, Pittarello Matilde, De Fazio Emerson, Gans Alessandro, Alimonti Paolo, Slika Hasan, Legnani Federico, Di Meco Francesco, Tyler Betty

Abstract excerpt

Pediatric high-grade glioma (pHGG) encompasses a wide range of gliomas with different genomic, epigenomic, and transcriptomic features. Almost 50% of pHGGs present a mutation in genes coding for histone 3, including the subtype harboring the H3.3-G34 mutation. In this context, histone mutations are frequently associated with mutations in TP53 and ATRX, along with PDGFRA and NOTCH2NL amplifications. Moreover, the...

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Identifiers

PMID: 39202398
DOI: 10.3390/genes15081038
PMCID: PMC11353413

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