Article
Diffuse pediatric high-grade glioma of methylation-based RTK2A and RTK2B subclasses present distinct radiological and histomolecular features including Gliomatosis cerebri phenotype.
Acta neuropathologica communications - 18 Nov 2024
Tauziède-Espariat Arnault, Friker Lea L, Nussbaumer Gunther, Bison Brigitte, Dangouloff-Ros Volodia, Métais Alice, Sumerauer David, Zamecnik Josef, Benesch Martin, Perwein Thomas, van Vuurden Dannis, Wesseling Pieter, La Madrid Andrés Morales, Garrè Maria Luisa, Antonelli Manila, Giangaspero Felice, Pietsch Torsten, Sturm Dominik, Jones David T W, Pfister Stefan M, Grabovska Yura, Mackay Alan, Jones Chris, Grill Jacques, Ajlil Yassine, von Bueren André O, Karremann Michael, Hoffmann Marion, Kramm Christof M, Kwiecien Robert, Castel David, Gielen Gerrit H, Varlet Pascale
Abstract excerpt
Diffuse pediatric-type high-grade gliomas (pedHGG), H3- and IDH-wildtype, encompass three main DNA-methylation-based subtypes: pedHGG-MYCN, pedHGG-RTK1A/B/C, and pedHGG-RTK2A/B. Since their first description in 2017 tumors of pedHGG-RTK2A/B have not been comprehensively characterized and clinical correlates remain elusive. In a recent series of pedHGG with a Gliomatosis cerebri (GC) growth pattern, an increased...
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