Comprehensive Genomic Profiling of 282 Pediatric Low- and High-Grade Gliomas Reveals Genomic Drivers, Tumor Mutational Burden, and Hypermutation Signatures.

doi:10.1634/theoncologist.2017-0242

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Comprehensive Genomic Profiling of 282 Pediatric Low- and High-Grade Gliomas Reveals Genomic Drivers, Tumor Mutational Burden, and Hypermutation Signatures.

The oncologist - 1 Dec 2017

Johnson Adrienne, Severson Eric, Gay Laurie, Vergilio Jo-Anne, Elvin Julia, Suh James, Daniel Sugganth, Covert Mandy, Frampton Garrett M, Hsu Sigmund, Lesser Glenn J, Stogner-Underwood Kimberly, Mott Ryan T, Rush Sarah Z, Stanke Jennifer J, Dahiya Sonika, Sun James, Reddy Prasanth, Chalmers Zachary R, Erlich Rachel, Chudnovsky Yakov, Fabrizio David, Schrock Alexa B, Ali Siraj, Miller Vincent, Stephens Philip J, Ross Jeffrey, Crawford John R, Ramkissoon Shakti H

Abstract excerpt

BACKGROUND: Pediatric brain tumors are the leading cause of death for children with cancer in the U.S. Incorporating next-generation sequencing data for both pediatric low-grade (pLGGs) and high-grade gliomas (pHGGs) can inform diagnostic, prognostic, and therapeutic decision-making. MATERIALS AND METHODS: We performed comprehensive genomic profiling on 282 pediatric gliomas (157 pHGGs, 125 pLGGs), sequencing 315...

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Identifiers

PMID: 28912153
DOI: 10.1634/theoncologist.2017-0242
PMCID: PMC5728033

Genes

BRAF
RAF1
ROS1
ALK
ATG7
ATRX
DGKB
EML4
ETV1
EWSR1
FGFR1
FGFR3
GOPC
MLH1
MSH2
MSH6
PATZ1
PDGFRA
PMS2
POLD1
POLE
QKI
TACC3

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