Article
Spatial genomic heterogeneity in diffuse intrinsic pontine and midline high-grade glioma: implications for diagnostic biopsy and targeted therapeutics.
Acta neuropathologica communications - 4 Jan 2016
Hoffman Lindsey M, DeWire Mariko, Ryall Scott, Buczkowicz Pawel, Leach James, Miles Lili, Ramani Arun, Brudno Michael, Kumar Shiva Senthil, Drissi Rachid, Dexheimer Phillip, Salloum Ralph, Chow Lionel, Hummel Trent, Stevenson Charles, Lu Q Richard, Jones Blaise, Witte David, Aronow Bruce, Hawkins Cynthia E, Fouladi Maryam
Abstract excerpt
INTRODUCTION: Diffuse intrinsic pontine glioma (DIPG) and midline high-grade glioma (mHGG) are lethal childhood brain tumors. Spatial genomic heterogeneity has been well-described in adult HGG but has not been comprehensively characterized in pediatric HGG. We performed whole exome sequencing on 38-matched primary, contiguous, and metastatic tumor sites from eight children with DIPG (n = 7) or mHGG (n = 1)...
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