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Article

Gliomas in children and adolescents: investigation of molecular alterations with a potential prognostic and therapeutic impact.

Journal of cancer research and clinical oncology - 1 Jan 2022

Cabral de Carvalho Corrêa Débora, Tesser-Gamba Francine, Dias Oliveira Indhira, Saba da Silva Nasjla, Capellano Andrea Maria, de Seixas Alves Maria Teresa, Dastoli Patrícia Alessandra, Cavalheiro Sergio, Caminada de Toledo Silvia Regina

Abstract excerpt

PURPOSE: Gliomas represent the most frequent central nervous system (CNS) tumors in children and adolescents. However, therapeutic strategies for these patients, based on tumor molecular profile, are still limited compared to the wide range of treatment options for the adult population. We investigated molecular alterations, with a potential prognostic marker and therapeutic target in gliomas of childhood and...

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PMID: 34626238
DOI: 10.1007/s00432-021-03813-1

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