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Epigenetic programming of pediatric high-grade glioma: Pushing beyond proof of concept to clinical benefit

14 Dec 2022

Abstract excerpt

Pediatric high-grade gliomas (pHGG) are a molecularly diverse group of malignancies, each incredibly aggressive and in dire need of treatment advancements. Genomic analysis has revolutionized our understanding of these tumors, identifying biologically relevant subgroups with differing canonical mutational profiles that vary based on tumor location and age. In particular, the discovery of recurrent histone H3...

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Share to Epigenetics and DNA Methylation
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PMID: 36589742
DOI: 10.3389/fcell.2022.1089898

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