Article

Structural variants shape driver combinations and outcomes in pediatric high-grade glioma

2021-04-14

Abstract excerpt

<title>Abstract</title> <p>Pediatric high-grade gliomas (pHGGs), encompassing hemispheric and diffuse midline gliomas (DMGs), remain a devastating disease. The last decade has revealed oncogenic drivers including single nucleotide variants (SNVs) in histones. However, the contribution of structural variants (SVs) to gliomagenesis has not been systematically explored due to limitations in early SV analysis approac...

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Literature Corpus work: 375f9825-527b-5736-abdb-844dc31abbe3
DOI: 10.21203/rs.3.rs-389596/v1

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