Article
H3-/IDH-wild type pediatric glioblastoma is comprised of molecularly and prognostically distinct subtypes with associated oncogenic drivers.
Acta neuropathologica - 1 Sept 2017
Korshunov Andrey, Schrimpf Daniel, Ryzhova Marina, Sturm Dominik, Chavez Lukas, Hovestadt Volker, Sharma Tanvi, Habel Antje, Burford Anna, Jones Chris, Zheludkova Olga, Kumirova Ella, Kramm Christof M, Golanov Andrey, Capper David, von Deimling Andreas, Pfister Stefan M, Jones David T W
Abstract excerpt
Pediatric glioblastoma (pedGBM) is an extremely aggressive pediatric brain tumor, accounting for ~6% of all central nervous system neoplasms in children. Approximately half of pedGBM harbor recurrent somatic mutations in histone 3 variants or, infrequently, IDH1/2. The remaining subset of pedGBM is highly heterogeneous, and displays a variety of genomic and epigenetic features. In the current study, we aimed to...
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