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Inferring models of multiscale copy number evolution for single-tumor phylogenetics

10 Jun 2015

Abstract excerpt

MOTIVATION: Phylogenetic algorithms have begun to see widespread use in cancer research to reconstruct processes of evolution in tumor progression. Developing reliable phylogenies for tumor data requires quantitative models of cancer evolution that include the unusual genetic mechanisms by which tumors evolve, such as chromosome abnormalities, and allow for heterogeneity between tumor types and individual...

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PMID: 26072490
DOI: 10.1093/bioinformatics/btv233

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