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Article

Polygenic Resilience Modulates the Penetrance of Parkinson Disease Genetic Risk Factors.

Annals of neurology - 1 Aug 2022

Liu Hui, Dehestani Mohammad, Blauwendraat Cornelis, Makarious Mary B, Leonard Hampton, Kim Jonggeol J, Schulte Claudia, Noyce Alastair, Jacobs Benjamin M, Foote Isabelle, Sharma Manu, Nalls Mike, Singleton Andrew, Gasser Thomas, Bandres-Ciga Sara

Abstract excerpt

OBJECTIVE: The aim of the current study is to understand why some individuals avoid developing Parkinson disease (PD) despite being at relatively high genetic risk, using the largest datasets of individual-level genetic data available. METHODS: We calculated polygenic risk score to identify controls and matched PD cases with the highest burden of genetic risk for PD in the discovery cohort (International...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 35599344
DOI: 10.1002/ana.26416
PMCID: PMC9329258

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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