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Article

Protective Effects of Genetic Proxies of Cognitive Reserve in Parkinson's Disease: A Longitudinal Multi-Cohort Study.

Movement disorders : official journal of the Movement Disorder Society - 1 Oct 2025

Huh Young Eun, Jang Beomjin, Jung Sang-Hyuk, Kim Dokyoon, Raj Towfique, Won Hong-Hee

Abstract excerpt

BACKGROUND: Resilience factors are crucial in the progression of neurodegenerative diseases. However, it remains unclear whether a genetic predisposition to cognitive reserve influences clinical heterogeneity in the prognosis of Parkinson's disease (PD). OBJECTIVES: The aim is to evaluate the utility of polygenic scores (PGSs) for cognitive reserve proxies, including intelligence (INT), educational attainment...

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Source

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Identifiers

PMID: 40557710
DOI: 10.1002/mds.30276
PMCID: PMC12302673

Genes

APOE
GBA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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