Article
Penetrance of Parkinson's Disease in LRRK2 p.G2019S Carriers Is Modified by a Polygenic Risk Score.
Movement disorders : official journal of the Movement Disorder Society - 1 May 2020
Iwaki Hirotaka, Blauwendraat Cornelis, Makarious Mary B, Bandrés-Ciga Sara, Leonard Hampton L, Gibbs J Raphael, Hernandez Dena G, Scholz Sonja W, Faghri Faraz, Nalls Mike A, Singleton Andrew B
Abstract excerpt
BACKGROUND: Although the leucine-rich repeat kinase 2 p.G2019S mutation has been demonstrated to be a strong risk factor for PD, factors that contribute to penetrance among carriers, other than aging, have not been well identified. OBJECTIVES: To evaluate whether a cumulative genetic risk identified in the recent genome-wide study is associated with penetrance of PD among p.G2019S mutation carriers. METHODS: We...
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