Article

Using polygenic and transcriptional risk scores to investigate psychiatric and cognitive symptoms in Parkinson’s disease

2025-03-20

Abstract excerpt

Psychiatric and cognitive symptoms are commonly observed in individuals with Parkinson’s disease (PD) with a significant impact on quality of life. Given the genetic contribution to PD, cross-trait polygenic risk score (PRS) analysis may elucidate underlying biological mechanisms. Transcriptional risk scores (TRS) – the weighted sum of an individual’s observed gene expression – offer a complementary approach, havi...

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Literature Corpus work: 116e44d5-58b3-53fd-b764-d77fc5b648d7
DOI: 10.1101/2025.03.20.25324166

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