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Polygenic Risk Scores Contribute to Personalized Medicine of Parkinson’s Disease

15 Oct 2021

Abstract excerpt

Parkinson's disease (PD) is the second most common neurodegenerative disorder characterized by the loss of dopaminergic neurons. The vast majority of PD patients develop the disease sporadically and it is assumed that the cause lies in polygenic and environmental components. The overall polygenic risk is the result of a large number of common low-risk variants discovered by large genome-wide association studies...

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PMID: 34683174
DOI: 10.3390/jpm11101030

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