Article
A cumulative genetic risk score predicts progression in Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society - 1 Apr 2016
Pihlstrøm Lasse, Morset Kristina Rebekka, Grimstad Espen, Vitelli Valeria, Toft Mathias
Abstract excerpt
BACKGROUND: The contribution of genetic variability to clinical heterogeneity in Parkinson's disease is insufficiently understood. We aimed to investigate the effect of cumulative genetic risk on clinical outcomes. METHODS: In a single-center study of 336 patients we genotyped 19 independent susceptibility variants identified in genome-wide association studies of Parkinson's disease. We tested for association...
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