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Article

A polygenic resilience score moderates the genetic risk for schizophrenia: Replication in 18,090 cases and 28,114 controls from the Psychiatric Genomics Consortium.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Mar 2024

Hess Jonathan L, Mattheisen Manuel, Greenwood Tiffany A, Tsuang Ming T, Edenberg Howard J, Holmans Peter, Faraone Stephen V, Glatt Stephen J

Abstract excerpt

Identifying heritable factors that moderate the genetic risk for schizophrenia (SCZ) could help clarify why some individuals remain unaffected despite having relatively high genetic liability. Previously, we developed a framework to mine genome-wide association (GWAS) data for common genetic variants that protect high-risk unaffected individuals from SCZ, leading to derivation of the first-ever "polygenic...

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PMID: 37551635
DOI: 10.1002/ajmg.b.32957
PMCID: PMC10850427

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PGC

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