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Article

Evidence of trem2 variant associated with triple risk of Alzheimer's disease.

PloS one - 1 Jan 2014

Abduljaleel Zainularifeen, Al-Allaf Faisal A, Khan Wajahatullah, Athar Mohammad, Shahzad Naiyer, Taher Mohiuddin M, Elrobh Mohamed, Alanazi Mohammed S, El-Huneidi Waseem

Abstract excerpt

Alzheimer's disease is one of the main causes of dementia among elderly individuals and leads to the neurodegeneration of different areas of the brain, resulting in memory impairments and loss of cognitive functions. Recently, a rare variant that is associated with 3-fold higher risk of Alzheimer's disease onset has been found. The rare variant discovered is a missense mutation in the loop region of exon 2 of...

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Source

Open in PubMed Open full text

Identifiers

PMID: 24663666
DOI: 10.1371/journal.pone.0092648
PMCID: PMC3963925

Genes

TREM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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