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Article

Dynamic insights into the effects of nonsynonymous polymorphisms (nsSNPs) on loss of TREM2 function.

Scientific reports - 7 Jun 2022

Dash Raju, Munni Yeasmin Akter, Mitra Sarmistha, Choi Ho Jin, Jahan Sultana Israt, Chowdhury Apusi, Jang Tae Jung, Moon Il Soo

Abstract excerpt

Single nucleotide variations in Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) are associated with many neurodegenerative diseases, including Nasu-Hakola disease (NHD), frontotemporal dementia (FTD), and late-onset Alzheimer's disease because they disrupt ligand binding to the extracellular domain of TREM2. However, the effects of nonsynonymous single nucleotide polymorphisms (nsSNPs) in TREM2 on...

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Identifiers

PMID: 35672339
DOI: 10.1038/s41598-022-13120-5
PMCID: PMC9174165

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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