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Mechanistic insights into the deleterious roles of Nasu-Hakola disease associated TREM2 variants

27 Feb 2020

Abstract excerpt

Recently, the critical roles played by genetic variants of TREM2 (Triggering Receptor Expressed on Myeloid cells 2) in Alzheimer's disease have been aggressively highlighted. However, few studies have focused on the deleterious roles of Nasu-Hakola disease (NHD) associated TREM2 variants. In order to get insights into the contributions made by these variants to neurodegeneration, we investigated the influences of...

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PMID: 32107424
DOI: 10.1038/s41598-020-60561-x

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